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Carotid endarterectomy and prevention of cerebral ischemia in symptomatic carotid stenosis

Journal Article · · JAMA, Journal of the American Medical Association; (United States)
; ; ;  [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8]
  1. Univ. of Washington, Seattle (United States)
  2. Univ. of California, Los Angeles (United States)
  3. Univ. of Texas, Houston (United States)
  4. Dept. of Veterans Affairs Cooperative Studies Program Coordinating Center, Perry Point, MD (United States)
  5. Univ. of Michigan, Ann Arbor (United States)
  6. State Univ. of New York, Buffalo (United States)
  7. Dept. of Veterans Affairs Cooperative Studies Program, Albuquerque, NM (United States)
  8. Dept. of Veterans Affairs Cooperative Studies Program, Boston, MA (United States)
+ Show Author Affiliations

The objective of this study was to determine whether carotid endarterectomy provides protection against subsequent cerebral ischemia in men with ischemic symptoms in the distribution of significant ipsilateral internal carotid artery stenosis. The study group was comprised of men who presented within 120 days of onset of symptoms that were consistent with transient ischemic attacks, transient monocular blindness, or recent small completed strokes between July 1988 and February 1991. Among 5,000 patients screened, 189 individuals were randomized with angiographic internal carotid artery stenosis greater than 50% ipsilateral to the presenting symptoms. Forty-eight eligible patients who refused entry were followed up outside of the trial. For a selected cohort of men with symptoms of cerebral or retinal ischemia in the distribution of a high-grade internal carotid artery stenosis, carotid endarterectomy can effectively reduce the risk of subsequent ipsilateral cerebral ischemia. The risk of cerebral ischemia in this subgroup of patients is considerably higher than previously estimated.

OSTI ID:
5484673
Journal Information:
JAMA, Journal of the American Medical Association; (United States), Journal Name: JAMA, Journal of the American Medical Association; (United States) Vol. 266:23; ISSN 0098-7484; ISSN JAMAA
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ARTERIES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EDEMA
HEMIC DISEASES
HEMORRHAGE
ISCHEMIA
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIOLOGY
RISK ASSESSMENT
SYMPTOMS
TOMOGRAPHY
VASCULAR DISEASES