Daily rhythms of benzodiazepine receptor numbers in frontal lobe and cerebellum of the rat
Journal Article
·
· Life Sci.; (United States)
Behavioral, biochemical and neurophysiological evidence suggests that gamma-aminobutyric acid (GABA) may play an important role in the neural control of circadian rhythms. Central receptors for benzodiazepines are functionally coupled to GABA receptors and appear to mediate behavioral effects of exogenous benzodiazepines. The binding of /sup 3/H-flunitrazepam to synaptic plasma membranes prepared from various regions of rat brain was examined at 6-hour intervals over a 36-hour period. Prominent daily rhythms in receptor number (Bmax) were observed in the frontal lobe and the cerebellum but not in the temporoparietal regions, hypothalamus or medulla/pons. Binding was highest during periods of sleep/low activity with a significant decrease occurring just prior to waking. These results suggest that daily fluctuations in benzodiazepine receptor numbers may be related to the temporal control of sleep/wake and muscle activity cycles. 23 references, 1 figure, 1 table.
- Research Organization:
- Boston City Hospital, MA
- OSTI ID:
- 5484029
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 36:24; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMISTRY
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
CHEMISTRY
DAILY VARIATIONS
DRUGS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
MUSCLES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RATS
RECEPTORS
RODENTS
TRANQUILIZERS
TRITIUM COMPOUNDS
VARIATIONS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMISTRY
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
CHEMISTRY
DAILY VARIATIONS
DRUGS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
MUSCLES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
RATS
RECEPTORS
RODENTS
TRANQUILIZERS
TRITIUM COMPOUNDS
VARIATIONS
VERTEBRATES