Delayed neovascularization in free skin flap transfer to irradiated beds in rats

Journal Article · Mon Apr 01 00:00:00 EST 1985 · Plast. Reconstr. Surg.; (United States)

DOI:https://doi.org/10.1097/00006534-198504000-00021· OSTI ID:5483655

Clarke, H M; Howard, C R; Pynn, B R; McKee, N H

A model for the study of neovascularization with a normal epigastric free flap set into an irradiated defect in the Fischer F344 rat is presented. In this model, both the administration of radiation and the flap transfer mimic the clinical situation. Significantly less tissue survives loss of the complete vascular pedicle at the second to fourth days following flap creation in rats with an irradiated bed. Later survival is not different from controls. Delayed neovascularization is proposed as the mechanism responsible for this effect during the period corresponding to the onset of the late phase of the response to skin radiation in rats. That neovascularization does occur, although delayed, suggests that the induced endarteritis may not be as important as previously suggested.

• Research Organization: Univ. of Toronto, Ontario, Canada
• OSTI ID: 5483655
• Journal Information: Plast. Reconstr. Surg.; (United States), Vol. 75:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARTERIES
BIOLOGICAL RADIATION EFFECTS
INFLAMMATION
SKIN
BIOLOGICAL MODELS
PLASTIC SURGERY
RATS
SURGERY
TIME DEPENDENCE
TRANSPLANTS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
MAMMALS
MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RODENTS
SYMPTOMS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals