Study of the toxicological effects of the inhalation of gaseous fluorine at a concentration of approximately 3 mg/m/sup 3/

Technical Report · Sun Sep 30 23:00:00 EST 1945

OSTI ID:5483051

Eriksen, N

The toxic effects arising from the daily inhalation of gaseous fluorine were studied in 4 animal species. Groups initially consisting of 5 dogs, 28 rabbits, 29 rats, and 24 guinea pigs, respectively, were exposed 6 days weekly, a total of 176 hours, to a concentration of fluorine approximating 3 mg/m/sup 3/ (2 ppM). Ten of the rabbits and 12 of the guinea pigs were subjected to head-exposure only. Toxicity was evaluated from the study of several independent factors: mortality, growth response, changes in tissue and in various constituents of the blood and urine. During the course of exposure 1 rat, 1 fully exposed guinea pig, 2 fully exposed rabbits, and 3 head-exposed rabbits died. The fully exposed rabbits in general lost weight, the dogs remained practically constant in weight, and the other animal groups gained, although the weight gain of the rats failed to keep pace with that of their controls. Interpretation of histopathological findings was made difficult by the presence of numerous lesions which were evidently unrelated to exposure. Whatever pathologic change was produced by exposure was entirely in the form of a mild pulmonary irritation.

• Research Organization: Rochester Univ., NY (USA)
• DOE Contract Number: AC02-76EV03490
• OSTI ID: 5483051
• Report Number(s): DOE/EV/03490-T2; ON: DE85010189
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BLOOD CHEMISTRY
BODY
DATA
DOGS
ELEMENTS
EXPERIMENTAL DATA
FLUORINE
GUINEA PIGS
HALOGENS
INFORMATION
INHALATION
INTAKE
LUNGS
MAMMALS
MORTALITY
NONMETALS
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
RABBITS
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES