Mortality patterns from lung cancer and nonneoplastic respiratory disease among white males in the Beryllium Case Registry

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90005-5· OSTI ID:5482392

Infante, P F ^[1]; Wagoner, J K; Sprince, N L

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1. Occupational Safety and Health Administration, Washington, DC

Study was undertaken of mortality patterns among white males entered into the Beryllium Case Registry (BCR) while alive with a diagnosis of beryllium-related nonneoplastic respiratory symptoms or disease. Analyses demonstrate an excessive risk of lung cancer among those subjects in the BCR who had been previously diagnosed with acute chemical pneumonitis or bronchitis secondary to short-term beryllium exposure. In the evaluation of the excessive lung cancer risk in this population, consideration should be given to the competing effects from the high case fatality rate of nonneoplastic respiratory disease. This excessive risk of lung cancer could not be explained on the basis of cigarette smoking per se. The findings of the present study utilizing subjects in the BCR are consistent with results of animal studies that over 30 years ago first demonstrated beryllium to be a carcinogen and with numerous epidemiologic studies demonstrating an increased risk of lung cancer among workers occupationally exposed to beryllium and its compounds.

• OSTI ID: 5482392
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 21:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
BERYLLIUM
BODY
CARCINOGENESIS
CARCINOMAS
DATA
DATA COMPILATION
DATA FORMS
DISEASES
ELEMENTS
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INFORMATION
LUNGS
METALS
MORTALITY
NEOPLASMS
NUMERICAL DATA
OCCUPATIONAL DISEASES
ORGANS
PATHOGENESIS
PERSONNEL
POPULATIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
TABLES