The biological effects of {sup 224}Ra injected into dogs
- Univ. of Utah School of Medicine, Salt Lake City, UT (United States)
The purpose of this study was to investigate the toxicity of injected {sup 224}Ra in the dog. Radium-224 is a short-lived isotope of radium with a half-life of 3.62 d. When administered parenterally, it deposits on bone surfaces; because of its short half-life, most of its energy is deposited on bone surfaces, in a manner similar to plutonium. The experimental design included a comparison to the exposed human population. Instead of using a single injection of {sup 224}Ra, groups were included in which dogs were injected once, 10 times, or 50 times. This design provided groups that could be compared to the multiple injections often used in people for the treatment of ankylosing spondylitis.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- DOE Contract Number:
- AC02-76EV00119; AC04-76EV01013
- OSTI ID:
- 54811
- Report Number(s):
- ITRI--144; ON: DE95007526
- Country of Publication:
- United States
- Language:
- English
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