Analysis of butadiene monoepoxide and butadiene diepoxide in various tissues of sprague-dawley rats and B6C3F{sub 1} mice following low-level exposures to 1,3-butadiene
1,3-Butadiene (BD) is used extensively in the production of styrene-butadiene rubber, polybutadiene elastomers, and other polymers. Occupational exposures of workers in areas with concentrations of up to 374 ppm BD have been documented in U.S. plants. Additionally, BD is present in cigarette smoke, gasoline vapors, and automobile exhaust resulting in exposures of this chemical to most of the U.S. population. Epidemiological studies have revealed increased incidences of mortality due to lymphatic and hematopoietic cancers among rubber industry workers exposed to BD. However, because these workers were most likely exposed to a wide variety of potentially harmful compounds, the contribution of BD to increased carcinogenic risk is uncertain. The purpose of the present investigation was to examine the production and disposition of BDO and BDO{sub 2} in several target tissues in rats and mice during and following 4-h exposures to a low-level (62.5 ppm) of BD.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 54801
- Report Number(s):
- ITRI-144; ON: DE95007526; TRN: 95:002409-0020
- Resource Relation:
- Other Information: PBD: Nov 1994; Related Information: Is Part Of Inhalation Toxicology Research Institute annual report, October 1, 1993--September 30, 1994; Belinsky, S.A.; Hoover, M.D.; Bradley, P.L. [eds.]; PB: 211 p.
- Country of Publication:
- United States
- Language:
- English
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