Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation

Journal Article · Fri Jan 15 04:00:00 EST 1988 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(88)90125-0· OSTI ID:5479758

Jager, M J; van der Pol, J P; de Wolff-Rouendaal, D; de Jong, P T; Ruiter, D J

In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.

• Research Organization: Univ. of Amsterdam, The Netherlands
• OSTI ID: 5479758
• Journal Information: Am. J. Ophthalmol.; (United States), Journal Name: Am. J. Ophthalmol.; (United States) Vol. 105:1; ISSN AJOPA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BODY
BODY AREAS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNOLOGY
IONIZING RADIATIONS
MEDICINE
MELANOMAS
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
THERAPY
UVEA
X RADIATION