Californium-252 interstitial implants in carcinoma of the tongue

Journal Article · Thu Feb 28 23:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90173-7· OSTI ID:5479689

Vtyurin, B M; Ivanov, V N; Medvedev, V S; Galantseva, G F; Abdulkadyrov, S A; Ivanova, L F; Petrovskaya, G A; Plichko, V I

A clinical study using /sup 252/Cf sources in brachytherapy of tumors began in the Research Institute of Medical Radiology of the Academy of Medical Sciences of the USSR in 1973. /sup 252/Cf afterloading cells were utilized by the method of simple afterloading. Dosimetry and radiation protection of medical personnel were developed. To substantiate optimal therapeutic doses of /sup 252/Cf neutrons, a correlation of dose, time, and treatment volume factors with clinical results of /sup 252/Cf interstitial implants in carcinoma of the tongue for 47 patients with a minimum follow-up period of 1 year was studied. Forty-nine interstitial implants have been performed. Seventeen patients received /sup 252/Cf implants alone (Group I), 17 other patients received /sup 252/Cf implants in combination with external radiation (Group II), and 15 patients were treated with interstitial implants for recurrent or residual tumors (Groups III). Complete regression of carcinoma of the tongue was obtained in 48 patients (98%). Thirteen patients (27%) developed radiation necrosis. The therapeutic dose of neutron radiation from /sup 252/Cf sources in interstitial radiotherapy of primary tongue carcinomas (Group I) was found to be 7 to 9 Gy. Optimal therapeutic neutron dose in combined interstitial and external radiotherapy of primary tumors (Group II) was 5 to 6 Gy with an external radiation dose of 40 Gy. For recurrent and residual tumors (Group III), favorable results were obtained with tumor doses of 6.5 to 7 Gy.

• Research Organization: Research Institute of Medical Radiology, Obninsk, USSR
• OSTI ID: 5479689
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
IMPLANTS
ISOTOPES
MEDICINE
NECROSIS
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ORAL CAVITY
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
TONGUE
ULCERS
YEARS LIVING RADIOISOTOPES