The development of new bifunctional chelates for imaging: Final progress report for period 1 September 1983 to 31 August 1987

Technical Report · Tue Sep 01 04:00:00 EDT 1987

OSTI ID:5479500

Hnatowich, D J

The primary object of research performed in this laboratory with support from the DOE has been the development of new ligands for the stable chelation of technetium-99m (/sup 99m/Tc). These chelators are intended first to be used to facilitate the labeling of proteins with this radionuclide and secondly as a means of attaching /sup 99m/Tc to biologically significant molecules of interest. With regard to protein labeling, this laboratory had earlier investigated the chelator diethylenetriaminepentaacetic acid (DTPA) for this purpose and eventually concluded that whereas DTPA is suitable for use with other radionuclides such as /sup 111/In, when used to bind /sup 99m/Tc, instability is apparent to a degree which may render the labeling unsuitable. Since our efforts in this direction, a number of other chelators have been tried in other laboratories as means of labeling proteins with /sup 99m/Tc. The only ligand which has thus far been described in detail is p-carboxyethylpenylglyoxal-di(N-methylthiosemicarbazone), or CE-DTS developed by investigators at Kyoto University in Japan. This chelator appears to possess many of the essential properties required for this application, although its use in patients has thus far not been described. 11 refs., 1 fig.

• Research Organization: Massachusetts Univ., Worcester (USA). Medical School
• DOE Contract Number: AC02-83ER60175
• OSTI ID: 5479500
• Report Number(s): DOE/ER/60175-T2; ON: DE88002353
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATES
CHELATING AGENTS
CHEMICAL PREPARATION
CHEMISTRY
COMPLEXES
DIAGNOSTIC USES
DOCUMENT TYPES
DRUGS
EDTA
GLOBULINS
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
IMMUNOGLOBULINS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONATES
PROCESSING
PROGRESS REPORT
PROTEINS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
UPTAKE
USES
YEARS LIVING RADIOISOTOPES