Derivatized cyclodextrins for normal-phase liquid chromatographic separation of enantiomers

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Analytical Chemistry (Washington); (United States)

DOI:https://doi.org/10.1021/ac00214a014· OSTI ID:5479429

Armstrong, D W; Stalcup, A M; Hilton, M L; Duncan, J D; Faulkner, Jr, J R; Chang, Sanchun ^[1]

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1. Univ. of Missouri, Rolla (USA)

Several different derivatized {beta}-cyclodextrins were synthesized and used as chiral stationary phases in normal-phase liquid chromatography. The multiply substituted derivatives were made with acetic anhydride, (R)- and (S)-1-(1-naphthyl)ethyl isocyanate, 2,6-dimethylphenyl isocyanate, and p-toluoyl chloride. The first successful cyclodextrin-based, normal-phase separation of enantiomers was accomplished on these derivative phases. In contrast to chiral separations on the native {beta}-cyclodextrin stationary phase, the enantiomeric separation mechanism on these new phases is not thought to be dependent on inclusion complexation. The similarities and differences between the derivatized cyclodextrin stationary phases and the cellulosic stationary phases are discussed.

• OSTI ID: 5479429
• Journal Information: Analytical Chemistry (Washington); (United States), Journal Name: Analytical Chemistry (Washington); (United States) Vol. 62:15; ISSN ANCHA; ISSN 0003-2700
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
CALCULATION METHODS
CARBOHYDRATES
CHROMATOGRAPHY
DEXTRIN
ENANTIOMORPHS
EXTRACTION APPARATUSES
EXTRACTION COLUMNS
LIQUID COLUMN CHROMATOGRAPHY
MEASURING METHODS
ORGANIC COMPOUNDS
POLYSACCHARIDES
SACCHARIDES
SEPARATION EQUIPMENT
SEPARATION PROCESSES