The effect of enteric galactose on neonatal canine carbohydrate metabolism

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Metabolism; (United States)

DOI:https://doi.org/10.1016/0026-0495(81)90056-1· OSTI ID:5479245

Kliegman, R M; Miettinen, E L; Kalhan, S C; Adam, P A

Newborn pups were assigned to a fasting group or to a group receiving intravenous glucose alimentation. Glucose turnover was determined during steady state equilibration of simultaneously infused (6-/sup 3/H) glucose. Thereafter, pups from each group received 0.625 g/Kg of either oral (U-/sup 14/C) galactose or (U-/sup 14/C) glucose. In fasted or intravenously alimented pups enteric glucose resulted in a rapid and sustained elevation of blood glucose concentrations. Systemic appearance of /sup 14/C label from enteric glucose increased rapidly as did the enrichment of blood (/sup 14/C) glucose specific activity. In those pups given enteric galactose, blood glucose values were equivalent to that in the glucose fed groups, however /sup 14/C appearing in blood glucose and blood glucose specific activity was significantly lower. The peak values for rates of appearance and disappearance of systemic glucose were significantly lower in pups fed galactose than among pups fed glucose. Glucose clearance was also significantly lower in these pups despite equivalent plasma insulin responses. Among fasting pups hepatic glycogen content was significantly higher in those given either oral glucose or galactose when compared to a completely starved control group. In contrast, among alimented pups galactose administration significantly enhanced hepatic glycogen content compared to those fed glucose. In addition, hepatic glycogen synthase (glucose-6-phosphate independent) activity was increased only among alimented pups fed galactose when compared to completely fasted pups. In conclusion these data suggest that following gastrointestinal galactose administration, hepatic carbohydrate uptake is augmented while glycogen synthesis may be enhanced. Augmented glycogen synthesis following galactose administration may reflect alterations in hepatic glycogen synthase activity or enhanced hepatic carbohydrate uptake.

• Research Organization: Department of Pediatrics, Case Western Reserve University at Cleveland Metropolitan General Hospital
• OSTI ID: 5479245
• Journal Information: Metabolism; (United States), Vol. 30:11
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GALACTOSE
BIOLOGICAL EFFECTS
GLUCOSE
METABOLISM
GLYCOGEN
BIOSYNTHESIS
BLOOD CHEMISTRY
CARBON 14 COMPOUNDS
DIET
DOGS
INSULIN
LIVER
NEONATES
NUTRITIONAL DEFICIENCY
TRITIUM COMPOUNDS
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
DIGESTIVE SYSTEM
GLANDS
HEXOSES
HORMONES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
POLYSACCHARIDES
SACCHARIDES
SYNTHESIS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques