In vitro dissolution of metal tritides
- Sandia National Labs., Albuquerque, NM (United States)
Metal tritides including titanium, zirconium, and erbium tritide have been used as components of neutron generators. These compounds can be released to the air as aerosols during fabrication, assembling, and testing of components or in accidental or fugitive releases, and as a result, workers may inhale them. Our understanding of metal tritides and their radiation dosimetry for internal exposure is very limited. Current radiation protection guidelines for metal tritide particles are based on the assumption that their biological behavior is similar to tritiated water which could be easily absorbed into body fluid, and, therefore, has a relatively short biological half-life (10 d). However, a few papers in the literature suggest that the solubility of metal tritide could be low. If this is true, the biological half-life of metal tritide particles and the dosimetry of inhalation exposure to these particles could be quite different from tritiated water, and this would have significant implications in the current health protection guidelines. The purpose of this study was to investigate the dissolution behavior of metal tritide particles in simulated biological fluids and in rats. Data from these studies will provide information with which to estimate the dosimetry of inhaled metal tritides. A dosimetric model can then be used as the technical basis for setting health protection limits, including annual limits on intake and derived air concentrations for DOE facilities.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 54791
- Report Number(s):
- ITRI-144; ON: DE95007526; TRN: 95:012736
- Resource Relation:
- Other Information: PBD: Nov 1994; Related Information: Is Part Of Inhalation Toxicology Research Institute annual report, October 1, 1993--September 30, 1994; Belinsky, S.A.; Hoover, M.D.; Bradley, P.L. [eds.]; PB: 211 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dissolution rate and radiation dosimetry of metal tritides
Dissolution rate and radiation dosimetry of metal tritides