Tissue decorporation of polonium-210 in rats by DMPA
Polonium-210 exposures, although rare, have occurred due to accidents in nuclear working environments. This alpha emitting radioactive element can bind thiols and thiol-containing proteins in vivo. Since thiol-containing chelating agents compete with many thiols for heavy metals, a number of these chelating agents have been investigated as protective agents against the lethal effects of /sup 210/Po and as tissue decorporating agents for it. Rats given /sup 210/Po (40 microCi/kg) ip had a median survival time (mst) of 39 days. The mst was increased to 106 days when N-(2,3-dimercaptopropyl)phthalamidic acid (DMPA), meso-dimercaptosuccinic acid (DMSA) or the Na salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) was administered sc (p less than .002). Decorporation studies were performed by giving rats /sup 210/Po (0.4 microCi) sc, followed by a series of thiol injections beginning one hour later. After 21 days, kidney levels of /sup 210/Po in rats given DMPA were only 28% of those of the untreated controls and significantly lower than those receiving DMSA, DMPS, N-acetyl-L-cysteine, or WR2721. After DMPA treatment, the /sup 210/Po levels of the spleen were 25% of the saline-treated control. DMPA appears to be a new and consistent decorporating agent for polonium-210.
- Research Organization:
- Univ. of Arizona, Tucson
- OSTI ID:
- 5478617
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 58:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHELATING AGENTS
RADIOSENSITIVITY EFFECTS
POLONIUM 210
TISSUE DISTRIBUTION
PHTHALIC ACID
RATS
SUCCINIC ACID
SULFONIC ACIDS
UNITHIOL
ALPHA DECAY RADIOISOTOPES
ANIMALS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DICARBOXYLIC ACIDS
DISTRIBUTION
DITHIOLS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLONIUM ISOTOPES
RADIOISOTOPES
REAGENTS
RODENTS
THIOLS
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells