High-dose gallium imaging in lymphoma

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(83)91212-3· OSTI ID:5477742

Anderson, K C; Leonard, R C; Canellos, G P; Skarin, A T; Kaplan, W D

The role of gallium-67 imaging in the management of patients with lymphoma, traditionally assessed using low tracer doses and the rectilinear scanner, was assessed when using larger doses (7 to 10 mCi) and a triple-peak Anger camera. Gallium scan results in 51 patients with non-Hodgkin's lymphoma and 21 patients with Hodgkin's disease were compared with simultaneous radiologic, clinical, and histopathologic reports. Subsequent disease course was also evaluated in light of radionuclide findings. Sensitivity and specificity of the scans were 0.90 or greater for both non-Hodgkin's lymphoma and Hodgkin's disease, and overall accuracy by site was 96 percent. Although there are insufficient numbers of pretreatment scans to allow any conclusions, our data suggest that newer approaches to gallium scanning in treated patients are (1) highly specific in all lymphomas and most sensitive in high-grade non-Hodgkin's lymphoma and Hodgkin's disease; (2) valuable in assessing the mediastinum in both non-Hodgkin's lymphoma and Hodgkin's disease; and (3) helpful adjuncts to computed tomographic scanning and ultrasonography in assessing abdominal node disease.

• Research Organization: Division of Medical Oncology, Sidney Farber Cancer Institute, Boston, Massachusetts
• OSTI ID: 5477742
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 75:2; ISSN AJMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CHEST
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
HODGKINS DISEASE
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
RADIATIONS
RADIOISOTOPES
TOMOGRAPHY
ULTRASONOGRAPHY
X RADIATION