A variable embryotoxic response to lead in different strains of hamsters

Journal Article · Fri Dec 01 04:00:00 EST 1978 · Environmental Research; (USA)

DOI:https://doi.org/10.1016/0013-9351(78)90036-1· OSTI ID:5477705

Gale, T F ^[1]

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1. Medical College of Georgia, Augusta (USA)

Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, and P 4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.

• OSTI ID: 5477705
• Journal Information: Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 17:3; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL VARIABILITY
ELEMENTS
FETUSES
GENETIC VARIABILITY
HAMSTERS
INJECTION
INTAKE
INTRAVENOUS INJECTION
LEAD
MAMMALS
METALS
MICE
PREGNANCY
RODENTS
TERATOGENESIS
VERTEBRATES