Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients
Journal Article
·
· Life Sci.; (United States)
Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. /sup 125/ I-BH CCK/sub 33/ specific binding was reduced by 40% (p < 0.02) in the hippocampus and by 20% (p < 0.01) in the frontal cortex of schizophrenic patients compared with controls. There were no differences in /sup 125/I-BH CCK/sub 33/ binding between the two groups in the amygdala, temporal cortex or caudate nucleus. 20 references, 1 figure, 2 tables.
- Research Organization:
- MRC Clinical Research Centre, Harwood, England
- OSTI ID:
- 5476711
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 36:5; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AUTOPSY
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEMBRANES
MENTAL DISORDERS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
TRACER TECHNIQUES
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AUTOPSY
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEMBRANES
MENTAL DISORDERS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
TRACER TECHNIQUES