Actinomyces israelii in osteoradionecrosis of the jaws. Histopathologic and immunocytochemical study of five cases

Journal Article · Wed Jun 01 00:00:00 EDT 1983 · Oral Surg., Oral Med., Oral Pathol.; (United States)

DOI:https://doi.org/10.1016/0030-4220(83)90374-2· OSTI ID:5475972

Happonen, R P; Viander, M; Pelliniemi, L; Aitasalo, K

Five surgically treated patients with osteoradionecrosis of the jaws are presented. The clinical history of the disease varied from 3 to 17 years. In three cases the progression of the disease was enhanced by surgical procedures performed in the irradiated area causing exfoliation of the premaxillary area in one case and spontaneous mandibular fracture in two cases. Actinomyces israelii was demonstrated in tissue sections of all five cases by using FITC-labeled specific antiserum and additionally with peroxidase-antiperoxidase method in one case. Candida was found in histologic sections of three cases. Radiation damage in the oral soft tissues and jawbones makes the atmosphere favorable for anaerobic microorganisms. The present results indicate that the role of A. israelii in the pathogenesis of osteoradionecrosis of the jaws has not been fully appreciated.

• Research Organization: Institute of Dentistry, University of Turku, Finland
• OSTI ID: 5475972
• Journal Information: Oral Surg., Oral Med., Oral Pathol.; (United States), Vol. 55:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
JAW
BIOLOGICAL RADIATION EFFECTS
PATHOLOGICAL CHANGES
ORAL CAVITY
OSTEORADIONECROSIS
ETIOLOGY
ACTINOMYCES
CANDIDA
FEMALES
IMMUNE REACTIONS
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RADIATION INJURIES
SKELETAL DISEASES
SKELETON
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560151* - Radiation Effects on Animals- Man