Neoplasia in fast neutron-irradiated beagles

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5475104

Bradley, E W; Zook, B C; Casarett, G W; Deye, J A; Adoff, L M; Rogers, C C

One hundred fifty-one beagle dogs were irradiated with either photons or fast neutrons (15 MeV) to one of three dose-limiting normal tissues--spinal cord, lung, or brain. The radiation was given in four fractions per week for 5 weeks (spinal cord), 6 weeks (lung), or 7 weeks (brain) to total doses encompassing those given clinically for cancer management. To date, no nonirradiated dogs or photon-irradiated dogs have developed any neoplasms. Seven dogs receiving fast neutrons have developed 9 neoplasms within the irradiated field. Of the neutron-irradiated dogs at risk, the incidence of neoplasia was 15%. The latent period for radiation-induced cancers has varied from 1 to 4 1/2 years at this time in the study.

• OSTI ID: 5475104
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
HADRONS
IRRADIATION
LATENCY PERIOD
LOCAL IRRADIATION
LUNGS
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NEUTRONS
NUCLEONS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RESPIRATORY SYSTEM
SPINAL CORD
VERTEBRATES