Activity of nitro-polynuclear aromatic hydrocarbons in the sister chromatid exchange assay with and without metabolic activation. [Hamsters]
Journal Article
·
· Environ. Mutagen.; (United States)
- Univ. of California, Berkeley
Nitro-polynuclear aromatic hydrocarbons are found in diesel particulates.These compounds are potent mutagens in the Ames test. To determine whether nitro-polynuclear aromatic hydrocarbons are active in a mammalian cell assay, 1-nitropyrene, 1,8-dinitropyrene, 2-nitrofluorene, and 4-nitrobiphenyl were incubated with cultures of Chinese hamster ovary cells. The frequency of sister chromatic exchange (SCE) was measured in the presence and absence of rat liver S-9 mix. The addition of S-9 mix resulted in a large increase in the SCEs induced by all four compounds.
- OSTI ID:
- 5474258
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 4:1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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·
Tue Oct 01 00:00:00 EDT 1985
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·
OSTI ID:5388026
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· Anal. Chem.; (United States)
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OSTI ID:5699757
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOASSAY
BODY
CELL CULTURES
CHROMOSOMAL ABERRATIONS
DIESEL FUELS
DIGESTIVE SYSTEM
FEMALE GENITALS
GLANDS
GONADS
HAMSTERS
HOMOGENATES
HYDROCARBONS
LIVER
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PARTICLES
PARTICULATES
PETROLEUM PRODUCTS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOASSAY
BODY
CELL CULTURES
CHROMOSOMAL ABERRATIONS
DIESEL FUELS
DIGESTIVE SYSTEM
FEMALE GENITALS
GLANDS
GONADS
HAMSTERS
HOMOGENATES
HYDROCARBONS
LIVER
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PARTICLES
PARTICULATES
PETROLEUM PRODUCTS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES