Evidence for repair capacity in mouse tumors relative to skin
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The repair capacity of six different types of mouse tumor has been tested by comparing regrowth delay curves for single doses and two or five fractions. The problem of reoxygenation has been avoided by making the tumors uniformly resistant or sensitive for each irradiation. The repair increments measured were mostly lower in the tumors than in skin. The data were analyzed in terms of the fractional recovered dose (F/sub R/). F/sub R/ values for these tumors at low doses averaged 20 to 50% compared with 65 to 90% for skin. It is postulated that this may result from a difference in the initial slope of the survival curve of tumor cells relative to normal cells, rather than from a difference in the value of D/sub Q/.
- Research Organization:
- Mount Vernon Hospital, Middlesex, England
- OSTI ID:
- 5473564
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:11-12; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
SURVIVAL CURVES
TABLES
THERAPY
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
SURVIVAL CURVES
TABLES
THERAPY
TUMOR CELLS
VERTEBRATES
X RADIATION