ESR study of electron-transfer reactions between gamma-irradiated pyrimidines, adriamycin, and oxygen. Scientific report
Technical Report
·
OSTI ID:5473524
The direct effect of ionizing radiation on DNA generates mainly guanine and thymine radicals. These radicals have been observed in solid DNA samples using electron spin resonance (ESR) spectroscopy. However, the exact fate of the guanine and thymine radicals when DNA is in solution is still unclear. One possibility of interest to this work, is the reaction of these radicals with other molecules in the solution generating products which may be harmful to cells. For this reason and as a model, the reaction between Gamma-irradiated pyrimidine bases with adriamycin was studied.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
- OSTI ID:
- 5473524
- Report Number(s):
- AD-A-231832/7/XAB; AFRRI-SR--90-25
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL REACTION KINETICS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
ELECTRON TRANSFER
ELEMENTS
GAMMA RADIATION
GUANINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KINETICS
MAGNETIC RESONANCE
MOLECULES
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
PURINES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADICALS
REACTION KINETICS
RESONANCE
SPECTROSCOPY
THYMINE
URACILS
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL REACTION KINETICS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
ELECTRON TRANSFER
ELEMENTS
GAMMA RADIATION
GUANINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KINETICS
MAGNETIC RESONANCE
MOLECULES
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
PURINES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADICALS
REACTION KINETICS
RESONANCE
SPECTROSCOPY
THYMINE
URACILS