Effects of dietary lead and zinc on fetal organ growth. [Rats]

Conference · Tue Apr 01 04:00:00 EST 1980 · Am. J. Obstet. Gynecol.; (United States)

OSTI ID:5473157

Dilts, Jr, P V; Ahokas, R A

In order to further understand the effects of ingested lead (Pb) on the fetus and the possible interaction of the trace element zinc (Zn) with Pb, groups of rats with dated pregnancies were fed 0, 10, 50, 100, 200, or 500 mg/L of Pb in water throughout pregnancy. Diet was provided ad libitum. A group pair fed with the 200 mg/L of Pb group and a group fed both Zn and Pb, 200 mg/L, were also studied. Placental weight remained constant, but cell division and total protein level were decreased while cell size increased markedly. Fetal carcass and liver weight, cell division, and protein were decreased while cell growth was unchanged. Brain weight decreased while cell division, growth, and protein were unchanged. Kidney weight, cell division, and protein level were unchanged but cell growth was decreased. Organ dry weight varied with wet weight while the percentage of water was unchanged. Whether pair feeding and Zn supplements improve carcass and liver weight is questionable.

• Research Organization: Univ. of Tennessee Coll. of Medicine, Memphis
• OSTI ID: 5473157
• Conference Information: Journal Name: Am. J. Obstet. Gynecol.; (United States) Journal Volume: 136:7
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
DATA
DATA FORMS
DIET
DISEASES
ELEMENTS
EXPERIMENTAL DATA
FEMALES
FETUSES
GROWTH
INFORMATION
INGESTION
INTAKE
ISOLATED VALUES
LEAD
MAMMALS
METALS
NUMERICAL DATA
ONTOGENESIS
PATHOLOGICAL CHANGES
PREGNANCY
RATS
RODENTS
VERTEBRATES
ZINC