Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning
An index of cerebral perfusion reserve (RES%), defined as the percent change of regional cerebral blood flow over baseline per mm Hg of end-tidal CO/sub 2/ tension, was determined for each middle cerebral artery (MCA) territory in patients with unilateral carotid distribution transient ischemic attacks or minor cerebrovascular accidents and was compared with that of age-matched, neurologically normal volunteers. Vasodilator responses to induced hypercapnia were tested during inhalation of 5% CO/sub 2/ in 95% O/sub 2/ while regional cerebral blood flow was measured by fluoromethane inhalation positron emission tomography. Mean RES% for 24 normal MCA territories was 5.2 +/- 0.8%. Mean RES% for 15 patient nonischemic MCA territories was 3.8 +/- 1.3% and for 15 ischemic MCA territories was 2.8 +/- 1.9% (both p less than 0.001). Individual RES% values and symmetry ratios between ischemic and nonischemic regions were also determined and compared with angiographic data. Areas of diminished, asymmetric, or paradoxical (two patients) CO/sub 2/ reactivity appear to correspond to areas of compensatory vasodilation. We found this technique to be a safe and reproducible method for defining and recording localized areas of cerebral tissue at apparent risk for hemodynamically related damage.
- Research Organization:
- William S. Middleton Memorial Veterans' Hospital, Madison, WI
- OSTI ID:
- 5470930
- Journal Information:
- Stroke; (United States), Journal Name: Stroke; (United States) Vol. 19:1; ISSN SJCCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cerebral blood flow asymmetry in the detection of extracranial cerebrovascular disease
Noninvasive testing of cerebral perfusion reserve prior to coronary artery bypass graft surgery
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
NERVOUS SYSTEM
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
PERFUSED ORGANS
POSITRON COMPUTED TOMOGRAPHY
TOMOGRAPHY
VASCULAR DISEASES
VASODILATION