The hamster flank organ model: Is it relevant to man
- Univ. of Washington, Seattle (USA)
The critical role that androgens play in the etiology of acne has led to a search for topically active antiandrogens and the frequent use of the flank organ of the golden Syrian hamster as an animal model. 17-alpha-propyltestosterone (17-PT) has been identified as having potent antiandrogenic activity in the hamster model, and this report describes its clinical evaluation. Two double-blind placebo controlled studies comparing 4% 17-PT in 80% alcohol versus vehicle alone were conducted. One study examined 17-PT sebosuppressive activity in 20 subjects. The second study examined its efficacy in 44 subjects having mild to moderate acne. A third study measured in vitro percutaneous absorption of 17-PT through hamster flank and monkey skin, and human face skin in-vivo, using radioactive drug. 17-PT was found to be ineffective in reducing either the sebum excretion rate or the number of inflammatory acne lesions. Failure of 17-PT to show clinical activity was not a result of poor percutaneous absorption. Total absorption in man was 7.7% of the dose and only 1.0% in the hamster. The sebaceous gland of hamster flank organ is apparently more sensitive to antiandrogens than the human sebaceous gland.
- OSTI ID:
- 5468212
- Journal Information:
- Journal of Investigative Dermatology; (USA), Journal Name: Journal of Investigative Dermatology; (USA) Vol. 93:4; ISSN 0022-202X; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MODELS
CARBON ISOTOPES
DISEASES
ETIOLOGY
FUNCTIONS
HAMSTERS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MAMMALS
MAN
MONKEYS
ORGANIC COMPOUNDS
PRIMATES
RODENTS
SKIN ABSORPTION
SKIN DISEASES
STEROID HORMONES
STEROIDS
TESTOSTERONE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES