Does the corticoadrenal adenoma with ''pre-Cushing's syndrome'' exist
An adrenal tumor was discovered fortuitously in a patient with no clinical features of Cushing's syndrome. On adrenal imaging, there was good uptake in the nodule but no visualization of the contralateral adrenal. The latter was seen, however, in a second scan performed under ACTH treatment. In the hormone assessment, basal cortisol and 17-hydroxycorticoids were normal and cortisol diurnal variation was near normal, but a dexamethasone suppression test and ACTH responses to metyrapone and insulin hypoglycemia were abnormal. Eight months after excision of a spongiocytic-type adenoma, the remaining adrenal was visible on scintigram and the hormonal tests were normal. This pattern suggests that the clinical Cushing's syndrome was enough to partially suppress ACTH and, consequently, visualization of the contralateral gland.
- Research Organization:
- Departement d'Endocrinologie, Clinique Medicale B, Hotel-Dieu, Nantes, France
- OSTI ID:
- 5466205
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:12; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTH
ADENOMAS
ADRENAL GLANDS
ADRENAL HORMONES
BODY
CORTICOSTEROIDS
COUNTING TECHNIQUES
CUSHING SYNDROME
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROCORTISONE
HYDROXY COMPOUNDS
IMAGES
KETONES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
RADIOISOTOPE SCANNING
SCINTISCANNING
STEROID HORMONES
STEROIDS