Mineral fiber concentration in lung tissue of mesothelioma patients in Finland
- Institute of Occupational Health, Helsinki (Finland)
The mineral fibers in lung tissue samples of 19 mesothelioma patients and 15 randomly selected autopsy cases were analyzed using low-temperature ashing, scanning electron microscopy (SEM) and x-ray microanalysis. The fiber concentration ranged from 0.5 to 370 million fibers per gram of dry tissue in the mesothelioma group and from less than 0.01 to 3.2 million fibers per gram of dry tissue in the autopsy group. In 80% of the mesothelioma patients and in 20% of the autopsy cases, the fiber concentration exceeded 1 million fibers per gram of dry tissue. Amphibole asbestos fibers predominated in both groups, and only a few chrysotile fibers were found. In the lungs of six mesothelioma patients, anthophyllite was the main fiber type. The overall analytical precision of sample preparation and fiber counting with SEM was 22%.
- OSTI ID:
- 5465760
- Journal Information:
- American Journal of Industrial Medicine; (USA), Vol. 16:3; ISSN 0271-3586
- Country of Publication:
- United States
- Language:
- English
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ASBESTOS
TOXICITY
LUNGS
NEOPLASMS
AUTOPSY
CARCINOGENESIS
ELECTRON MICROPROBE ANALYSIS
FINLAND
PATIENTS
SCANNING ELECTRON MICROSCOPY
BODY
CHEMICAL ANALYSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON MICROSCOPY
EUROPE
MICROANALYSIS
MICROSCOPY
ORGANS
PATHOGENESIS
RESPIRATORY SYSTEM
SCANDINAVIA
560300* - Chemicals Metabolism & Toxicology