Sequential half-body irradiation as systemic treatment of progressive Ewing sarcoma

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90286-3· OSTI ID:5464950

Lombardi, F; Lattuada, A; Gasparini, M; Gianni, C; Marchesini, R

Sequential half-body irradiation (HBI) to be delivered in two session was used in 18 consecutive patients with metastastic Ewing sarcoma who relapsed after radiotherapy and multidrug chemotherapy. The HIB program to both upper and lower hemi body was completed in 11 patients (61%). The remaining 7 patients received only one single treatment of HBI because of relapse before the completion of the treatment program. In 20 of the 29 sessions HBI was employed to treat overt metastases. The overall objective response rate was 50%. Six of 18 patients (33%) are alive from 4 to 27 months, 3 of them without evidence of disease. No severe toxicity was observed. HBI as systemic treatment was more effective in patients who relapsed while off chemotherapy, with metatases confined to the lungs or to one single bone segment.

• Research Organization: Istituto Nazionale per lo Studio e la Cura dei Tumori Via Venezian, Milan, Italy
• OSTI ID: 5464950
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:10
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
SIDE EFFECTS
SARCOMAS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
METASTASES
PARTIAL BODY IRRADIATION
PATIENTS
BIOLOGICAL EFFECTS
DISEASES
EXTERNAL IRRADIATION
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)