Neuronal modulation of calcium channel activity in cultured rat astrocytes

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.87.11.4345· OSTI ID:5464556

Corvalan, V; Cole, R; De Vellis, J; Hagiwara, Susumu ^[1]

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1. Univ. of California-Los Angeles School of Medicine (USA)

The patch-clamp technique was used to study whether cocultivation of neurons and astrocytes modulates the expression of calcium channel activity in astrocytes. Whole-cell patch-clamp recordings from rat brain astrocytes cocultured with rat embryonic neurons revealed two types of voltage-dependent inward currents carried by Ca{sup 2+} and blocked by either Cd{sup 2+} or Co{sup 2+} that otherwise were not detected in purified astrocytes. This expression of calcium channel activity in astrocytes was neuron dependent and was not observed when astrocytes were cocultured with purified oligodendrocytes.

• OSTI ID: 5464556
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:11; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
BIOLOGY
CADMIUM COMPOUNDS
CALCIUM COMPOUNDS
CATIONS
CELL CULTURES
CHARGED PARTICLES
COBALT COMPOUNDS
CYTOLOGY
IONS
MAMMALS
MEMBRANE TRANSPORT
NERVE CELLS
RATS
RODENTS
SOMATIC CELLS
TRANSITION ELEMENT COMPOUNDS
TUMOR CELLS
VERTEBRATES