Changing annual incidence of hypothyroidism after iodine-131 therapy for hyperthyroidism, 1951-1975
The incidence of hypothyroidism was analyzed in 4,553 hyperthyroid patients treated with I-131 between 1951 and 1975. The average annual rate of hypothyroidism during the first 7 yr after therapy increased continuously for each 5-yr period of treatment, from 3.6% for patients treated between 1951 and 1955 to 7.7% for patients treated during the period from 1971 though 1975 (p less than 0.001). The increase in the incidence of hypothyroidism was seen before the introduction of TSH assays and when allowance was made for thyroid gland size, the age of the patient, and the experience of the radiotherapist. The use of TSH assays has probably resulted in an earlier recognition of hypothyroidism, which may explain why the most marked rise in the incidence of hypothyroidism was observed after the introduction of TSH assays.
- Research Organization:
- Karolinska Hospital, Stockholm, Sweden
- OSTI ID:
- 5462794
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:2
- Country of Publication:
- United States
- Language:
- English
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Incidence of hypothyroidism occurring long after iodine-131 therapy for hyperthyroidism
Incidence of hypothyroidism occurring long after iodine-131 therapy for hyperthyroidism
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
HYPOTHYROIDISM
ANNUAL VARIATIONS
DIAGNOSIS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
THYROID
DELAYED RADIATION EFFECTS
EPIDEMIOLOGY
HYPERTHYROIDISM
IODINE 131
PATIENTS
TSH
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
THERAPY
VARIATIONS
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)