Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The characterization of radioaerosol deposition in the healthy lung by histogram distribution analysis

Journal Article · · Chest; (United States)
; ; ;
Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.
Research Organization:
Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois at the Medical Center, Chicago
OSTI ID:
5462700
Journal Information:
Chest; (United States), Journal Name: Chest; (United States) Vol. 80:6 Suppl; ISSN CHETB
Country of Publication:
United States
Language:
English

Similar Records

Analysis of aerosol deposition in the healthy human lung
Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Arch. Environ. Health; (United States) · OSTI ID:5704576
Relationships of aerosol deposition, lung size, and the rate of mucociliary clearance
Journal Article · Tue Dec 31 23:00:00 EST 1985 · Arch. Environ. Health; (United States) · OSTI ID:5681454
The effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects
Journal Article · Mon Jul 01 00:00:00 EDT 1991 · American Review of Respiratory Disease (New York); (United States) · OSTI ID:5447886

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOMEDICAL RADIOGRAPHY
BODY
CAMERAS
COLLOIDS
DIAGNOSTIC TECHNIQUES
DISPERSIONS
DYNAMIC FUNCTION STUDIES
GAMMA CAMERAS
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOACTIVE AEROSOLS
RADIOLOGY
RESPIRATORY SYSTEM
RETENTION
SOLS
VERTEBRATES