Radioprotection of mice with interleukin-1: Relationship to the number of erythroid and granulocyte-macrophage colony-forming cells

Technical Report · Mon Jan 01 04:00:00 EST 1990

OSTI ID:5459358

Schwartz, G N; Patchen, M L; Neta, R; MacVittie, T J

This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in the peripheral blood and changes in the tissue distribution of GM-CFC demonstrated that cells were mobilized from the bone marrow in response to rIL-1 injection. For example, 20 h after rIL-1 injection marrow GM-CFC numbers were 80% of the numbers in bone marrow from saline-injected mice. Associated with this decrease there was a twofold increase in the number of peripheral blood and splenic GM-CFC. Also, as determined by hydroxyurea injection, there was an increase in the number of GM-CFC in S phase of the cell cycle in the spleen, but not in the bone marrow. Data in this report suggest that when compared to the spleen, stimulation of granulopoiesis after rIL-1 injection is delayed in the bone marrow.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
• OSTI ID: 5459358
• Report Number(s): AD-A-235471/0/XAB; AFRRI-SR--91-21
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL CYCLE
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISTRIBUTION
ERYTHROCYTES
GROWTH FACTORS
HEMATOPOIETIC SYSTEM
HYDROXY COMPOUNDS
HYDROXYUREA
LYMPHOKINES
MACROPHAGES
MAMMALS
MATERIALS
MICE
MITOGENS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RADIOSENSITIVITY EFFECTS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
SPLEEN
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES