Preneoplastic transformation of rat tracheal epithelial cells by inhaled radon progeny
Conference
·
OSTI ID:5459068
Because all individuals are exposed to alpha radiation from inhaled radon progeny, we conducted research to address a basic question concerning the role of inhaled radon progeny in respiratory carcinogenesis: Does inhalation of radon progeny induce the early, preneoplastic changes involved in respiratory carcinogenesis The rat tracheal cell was our model for experimental carcinogenesis. These results demonstrate that (1) respiratory cells exposed in vivo sustained biologically damaging doses of radiation from inhaled radon progeny, (2) inhaled radon-progeny-induced preneoplastic changes in respiratory cells, and (3) radon-progeny-damaged cells were repaired, or lost in vivo with time after exposure. This model of respiratory carcinogenesis is useful for characterizing the role of inhaled radon progeny in respiratory carcinogenesis and for defining the risk from exposure. 37 refs., 1 figs., 1 tab.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5459068
- Report Number(s):
- CONF-901010-7; ON: DE91017508
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENESIS
CELL TRANSFORMATIONS
CHARGED PARTICLES
COLLOIDS
DAUGHTER PRODUCTS
DISEASES
DISPERSIONS
ELEMENTS
FLUIDS
GASES
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
ISOTOPES
LOCAL RADIATION EFFECTS
MAMMALS
NEOPLASMS
NONMETALS
PATHOGENESIS
RADIATION EFFECTS
RADIATION HAZARDS
RADIOINDUCTION
RADON
RARE GASES
RATS
RECOVERY
REPAIR
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RISK ASSESSMENT
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
TOXICITY
TRACHEA
VERTEBRATES
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGENESIS
CELL TRANSFORMATIONS
CHARGED PARTICLES
COLLOIDS
DAUGHTER PRODUCTS
DISEASES
DISPERSIONS
ELEMENTS
FLUIDS
GASES
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
ISOTOPES
LOCAL RADIATION EFFECTS
MAMMALS
NEOPLASMS
NONMETALS
PATHOGENESIS
RADIATION EFFECTS
RADIATION HAZARDS
RADIOINDUCTION
RADON
RARE GASES
RATS
RECOVERY
REPAIR
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RISK ASSESSMENT
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
TOXICITY
TRACHEA
VERTEBRATES