Effect of 8-methoxypsoralen-plus ultraviolet light on cell-virus interaction: the transforming infection; effect of PUVA on the transformation of baby hamster kidney cells by polyma virus
Journal Article
·
· J. Invest. Dermatol.; (United States)
Pre-treatment of baby hamster kidney (BHK) cells with 8-methoxypsoralen (8-MOP) plus ultraviolet (UV) light enhances the frequency of their transformation by polyoma (Py) virus. Of the doses tested, 0.5 microgram/m1 8-MOP plus 0 . 3 J/cm2 UV-light results in maximal (30-fold) stimulation of viral transformation. 8-MOP alone does not affect viral transformation and UV-light alone causes only a slight increase in the transformation frequency. Thus the drug and light act synergistically in promoting the effect. Treatment of BHK cells with drug plus light without Py infection does not lead to a transformed morphology. A drug-light combination (0 . 01 microgram/m1 8-MOP plus 1 . 2 J/cm2 UV) that inhibits cellular DNA synthesis is 75% of control at 28 hr after treatment results in a 6-fold stimulation of the transformation frequency.
- Research Organization:
- Stanford Univ. Medical Center, CA
- OSTI ID:
- 5458423
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 72:3; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
550700 -- Microbiology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
HAMSTERS
KIDNEYS
MAMMALS
MICROORGANISMS
MORPHOLOGICAL CHANGES
ONCOGENIC TRANSFORMATIONS
ORGANS
PARASITES
RADIATIONS
RESPONSE MODIFYING FACTORS
RODENTS
SYNERGISM
ULTRAVIOLET RADIATION
VERTEBRATES
VIRUSES
550700 -- Microbiology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
HAMSTERS
KIDNEYS
MAMMALS
MICROORGANISMS
MORPHOLOGICAL CHANGES
ONCOGENIC TRANSFORMATIONS
ORGANS
PARASITES
RADIATIONS
RESPONSE MODIFYING FACTORS
RODENTS
SYNERGISM
ULTRAVIOLET RADIATION
VERTEBRATES
VIRUSES