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Bromocaffeine, a haloid analogue of purine bases, used to inhibit repair of single-stranded breaks in mammalian cell DNA. [Cultured LL cells]

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5458364
; ; ;
A study was made of the effect of 8-bromocaffeine, a radiosensitizing agent, on repair of single-stranded breaks in the DNA of LL cells following exposure to x rays in a dosage of 5000 rad. Two techniques (sedimentation in a gradient of alkaline saccharose and separation of single and double helical fragments of DNA on a column with hydroxyapatite) were used to prove the effect of postradiation repair of single-stranded breaks in the DNA of the above line of cells. Addition of 8-bromocaffeine to the culture medium immediately after irradiation leads to substantial inhibition of the process of repair of single-stranded DNA breaks.
Research Organization:
Central Scientific Research Inst. of Roentgenology and Radiology, Leningrad, USSR
OSTI ID:
5458364
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:4; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CAFFEINE
CELL CULTURES
DATA
DATA FORMS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
INFORMATION
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RIBOSIDES
STRAND BREAKS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
X RADIATION
XANTHINES