Lymphocyte:monocyte ratio: B- and T-cell ratio after radiotherapy, chemotherapy, and surgery

Journal Article · Mon Oct 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90569-8· OSTI ID:5457767

Smit, B; Stjernswaerd, J; Dowdle, E; Sealy, G R; Wilson, E; Beatty, D; Jacobs, P; Bennett, M B

Differential white blood cell counts were taken from 42 previously untreated patients with mammary carcinoma who received radiotherapy, 10 patients with Stage III mammary carcinoma who received chemotherapy, 19 patients previously treated by a simple mastectomy, and 42 untreated patients. The percentage of B- and T-cells in the peripheral blood also was measured. Severe lymphopenia was seen in patients treated with radiotherapy and chemotherapy. The percentage of B- and T-cells remained constant before and after radiotherapy, and there was no selective depression of T-cells. The monocyte count, 3 months after radiotherapy, was significantly higher than the pre-treatment mean count. The percentage of B- and T-cells in the peripheral blood remained unchanged before and after treatment with chemotherapy. The mean lymphocyte counts following surgery were slightly higher than the control values whereas the monocyte counts were slightly lower than the control values. Surgery did not appear to influence the percentages of B- and T-cells in the peripheral blood.

• Research Organization: Univ. of Cape Town, South Africa
• OSTI ID: 5457767
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:10; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
CARCINOMAS
CELL KILLING
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DRUGS
ENDOXAN
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GLANDS
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LEUKOPENIA
LYMPHOCYTES
LYMPHOPENIA
MAMMARY GLANDS
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MONOCYTES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
SURGERY
SYMPTOMS
THERAPY
TIME DEPENDENCE
TOXICITY
YEARS LIVING RADIOISOTOPES