Effects of halothane on protein synthesis and degradation in rabbit pulmonary macrophages
Journal Article
·
· Am. Rev. Respir. Dis.; (United States)
OSTI ID:5455635
The effects of exposure to the volatile anesthetic halothane on the synthesis and degradation of rabbit pulmonary macrophage proteins were investigated. Protein synthesis was inhibited rapidly and reversibly when macrophages were exposed to halothane. The magnitude of the inhibition was dependent upon the dose of anesthetic and upon the composition of the medium. The effect of halothane was not associated with increased cell death or with depletion of cellular ATP. Halothane exposure did not affect the ability of the cells to degrade either endogenous proteins or exogenous bovine serum albumin. These results suggested that halothane exposure favored protein catabolism in pulmonary alveolar macrophages though an inhibition of protein synthesis with no change in protein degradation.
- OSTI ID:
- 5455635
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 124:1; ISSN ARRDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANESTHETICS
ANIMAL CELLS
ANIMALS
ATP
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONNECTIVE TISSUE CELLS
DEATH
DRUGS
LUNGS
MACROPHAGES
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RABBITS
RESPIRATORY SYSTEM
SENSITIVITY
SOMATIC CELLS
VERTEBRATES
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANESTHETICS
ANIMAL CELLS
ANIMALS
ATP
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONNECTIVE TISSUE CELLS
DEATH
DRUGS
LUNGS
MACROPHAGES
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RABBITS
RESPIRATORY SYSTEM
SENSITIVITY
SOMATIC CELLS
VERTEBRATES