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Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated

Journal Article · · Cell Regulation; (United States)
DOI:https://doi.org/10.1091/mbc.1.10.781· OSTI ID:5451880
; ; ; ;  [1]
  1. Johns Hopkins University School of Public Health, Department of Toxicology, Baltimore, MD (USA)
Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate (I(1,4,5)P3) inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.
OSTI ID:
5451880
Journal Information:
Cell Regulation; (United States), Journal Name: Cell Regulation; (United States) Vol. 1:10; ISSN 1044-2030; ISSN CELRE
Country of Publication:
United States
Language:
English