Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study
We report a prospective study to evaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of I-131 (RAI) therapy. Twenty-four male patients with toxic diffuse goiter were assigned randomly into two treatment groups: Group A received RAI treatment while on antithyroid drugs after attainment of euthyroidism; Group B received no antithyroid drugs before, or when, RAI was given. Patients in each group received a dose of RAI calculated to deliver approximately 5000 rads per treatment. The incidence of hypothyroidism at 12 mo was 8% for Group A and 36% for Group B (p < 0.01). During 12 to 102 mo of follow-up, no additional hypothyroidism was encountered in Group A. Two patients with significantly elevated TSH levels were found in Group B, one at 20 mo and one at 75 mo after RAI. The mean time to cure was 15.2 +- 9.1 mo for Group A and 19.7 +- 8.2 Mo for Group B (NS: p > 0.45). The improved therapeutic outcome of patients in Group A suggests that further validation of the method in a larger patient population, including females, is warranted.
- Research Organization:
- Veterans Administration Medical Center, Buffalo, NY
- OSTI ID:
- 5451786
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:12
- Country of Publication:
- United States
- Language:
- English
Similar Records
THYROID ABLATION WITH I$sup 131$ IN EUTHYROID CARDIAC PATIENTS, WITH SPECIAL REFERENCE TO PREPARATION WITH ANTITHYROID DRUGS
Does thyroidectomy, radioactive iodine therapy, or antithyroid drug treatment alter reactivity of patients` T cells to epitopes of thyrotropin receptor in autoimmune thyroid diseases?
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTITHYROID DRUGS
RADIOSENSITIVITY EFFECTS
GOITER
RADIOTHERAPY
IODINE 131
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MALES
PATIENTS
SULFHYDRYL RADICALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ENDOCRINE DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADICALS
RADIOISOTOPES
RADIOLOGY
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man