Inhibitory effect of bombesin and SMS 201-995 on DNA synthesis in the rat thyroid lobes incubated in vitro
Journal Article
·
· Biochemical and Biophysical Research Communications; (United States)
- Institute of Endocrinology, University School of Medicine (Poland)
The effects of 4-h incubation in the presence of bombesin on the incorporation of (3H)-thymidine into DNA of the rat thyroid lobes, collected from animals treated in vivo with a long-acting somatostatin analog (SMS 201-995) or with 0.9% NaCl, were investigated. It was shown that not only in vivo injections of SMS 201-995, but also, unexpectedly, in vitro incubation with bombesin inhibited (3H)-thymidine incorporation. The two examined substances did not reveal any additive action in their inhibitory effects on the thyroid growth.
- OSTI ID:
- 5451628
- Journal Information:
- Biochemical and Biophysical Research Communications; (United States), Journal Name: Biochemical and Biophysical Research Communications; (United States) Vol. 178:2; ISSN BBRCA; ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Inhibitory effect of somatostatin on the basal and TSH-stimulated /sup 3/H-thymidine incorporation into rat thyroid lobes incubated in vitro
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Effect of subcutaneous injection of a long-acting analogue of somatostatin (SMS 201-995) on plasma thyroid-stimulating hormone in normal human subjects
Journal Article
·
Fri Jul 15 00:00:00 EDT 1988
· Biochem. Biophys. Res. Commun.; (United States)
·
OSTI ID:6829305
Somatostatin analog (SMS 201-995) inhibits the basal and angiotensin II-stimulated sup 3 H-thymidine uptake by rat adrenal glands
Journal Article
·
Tue Feb 13 23:00:00 EST 1990
· Biochemical and Biophysical Research Communications; (USA)
·
OSTI ID:6945544
Effect of subcutaneous injection of a long-acting analogue of somatostatin (SMS 201-995) on plasma thyroid-stimulating hormone in normal human subjects
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Life Sci.; (United States)
·
OSTI ID:6945468
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BODY
DNA
DNA REPLICATION
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IN VITRO
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
PYRIMIDINES
RATS
REACTION KINETICS
RIBOSIDES
RODENTS
SOMATOSTATIN
THYMIDINE
THYROID
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BODY
DNA
DNA REPLICATION
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IN VITRO
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
PYRIMIDINES
RATS
REACTION KINETICS
RIBOSIDES
RODENTS
SOMATOSTATIN
THYMIDINE
THYROID
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES