Relative contributions of parenchymal and non-parenchymal (sinusoidal) liver cells in the uptake of chylomicron remnants

Journal Article · Sat Aug 01 00:00:00 EDT 1981 · Metabolism; (United States)

DOI:https://doi.org/10.1016/0026-0495(81)90025-1· OSTI ID:5451180

Groot, P H; Van Berkel, T J; Van Tol, A

The relative contributions of parenchymal cells and non-parenchymal (sinusoidal) cells to the in vivo hepatic uptake of chylomicron remnants was measured 30 min after intravenous injection into rats. The chylomicron remnants were labeled with (3H)leucine, which was almost exclusively present in apolipoprotein B. The isolated non-parenchymal cells (a mixture of Kupffer cells and endothelial cells) contained 6.7 times more apolipoprotein B radioactivity per mg cell protein than the isolated parenchymal cells. It was calculated that the contributions of non-parenchymal and parenchymal liver cells to the total hepatic uptake of chylomicron remnants are 35% and 65%, respectively.

• OSTI ID: 5451180
• Journal Information: Metabolism; (United States), Journal Name: Metabolism; (United States) Vol. 30:8; ISSN MTBMA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
GLANDS
IN VIVO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUCINE
LIVER
MAMMALS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
RATS
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES