Increased amino acid transport into brain tumors measured by PET of L-(2-18F)fluorotyrosine
- Max-Planck-Institut fuer neurologische Forschung, Koeln (Germany)
The uptake of L-(2-18F)fluorotyrosine (F-Tyr), a newly synthetized amino acid tracer, was studied in 15 patients with various brain tumors by dynamic PET. The higher F-Tyr accumulation in tumors (mean 27% above contralateral tissue) was associated with two-fold transport rates into tumors, while the rate constants describing irreversible incorporation were decreased. The increased F-Tyr transport was not correlated to 68Ga-EDTA accumulation and cannot be explained by disruption of the blood-brain barrier. Kinetic analysis of 2-(18F)-fluoro-deoxy-glucose accumulation in the same patients demonstrated that increased metabolic rates in tumors are mainly caused by altered phosphorylation rates while transport of glucose is less affected. Since F-Tyr transport rates clearly separated tumors from normal tissue and since F-Tyr accumulation was related to tumor grade, PET studies of F-Tyr uptake are of clinical value for diagnosis and classification of brain tumors.
- OSTI ID:
- 5450469
- Journal Information:
- Journal of Nuclear Medicine; (United States), Vol. 32:7; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
NEOPLASMS
GLUCOSE
METABOLISM
DIAGNOSIS
TYROSINE
MEMBRANE TRANSPORT
BLOOD-BRAIN BARRIER
EDTA
FLUORINE 18
GALLIUM 68
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
ALDEHYDES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
GALLIUM ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics