Protein kinase C is present in human sperm: Possible role in flagellar motility
Journal Article
·
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
- Tel Aviv Univ. (Israel) Tel Aviv Medical Center (Israel)
- Tel Aviv Medical Center (Israel)
- Tel Aviv Univ. (Israel)
The authors report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility that was blocked by known PKC inhibitors such as sphingosine, staurosporine, and 1-(5-isoquinoylinylsulfonyl)-2-methylpiperazine. A very good correlation was found between the percentage of PKC-stained sperm cells and motility. They propose that PKC is involved in the regulation of flagellar motility in human sperm.
- OSTI ID:
- 5447998
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:18; ISSN 0027-8424; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CARCINOGENS
CHEMISTRY
CYTOCHEMISTRY
DAYS LIVING RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
ESTERS
GAMETES
GERM CELLS
ISOTOPES
LIGHT NUCLEI
MONOCLONAL ANTIBODIES
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHORBOL ESTERS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RADIOISOTOPES
SPERMATOZOA
TRANSFERASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CARCINOGENS
CHEMISTRY
CYTOCHEMISTRY
DAYS LIVING RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
ESTERS
GAMETES
GERM CELLS
ISOTOPES
LIGHT NUCLEI
MONOCLONAL ANTIBODIES
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHORBOL ESTERS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RADIOISOTOPES
SPERMATOZOA
TRANSFERASES