Molecular evolution of serpins: homologous structure of the human. cap alpha. /sub 1/-antichymotrypsin and. cap alpha. /sub 1/-antitrypsin genes
Journal Article
·
· Biochemistry; (United States)
OSTI ID:5446055
..cap alpha../sub 1/-Antichymotrypsin belongs to a supergene family that includes ..cap alpha../sub 1/-antitrypsin, antithrombin III, ovalbumin, and angiotensinogen. The human chromosomal ..cap alpha../sub 1/-antichymotrypsin gene has been cloned and its molecular structure established. The gene is approximately 12 kb in length and contains five exons and four introns. The locations of the introns within the ..cap alpha../sub 1/-antichymotrypsin gene are identical with those of the human ..cap alpha../sub 1/-antitrypsin and angiotensinogen genes. Other members of this supergene family contain introns located at nonhomologous positions of the genes. The homologous organization of the ..cap alpha../sub 1/-antichymotrypsin and ..cap alpha../sub 1/-antitrypsin genes corresponds with the high degree of homology between their protein sequences and suggest that these loci arose by recent gene duplication. A model is presented for the evolution of both the genomic structure and the protein sequences of the serine protease inhibitor superfamily.
- Research Organization:
- Howard Hughes Medical Institute, Houston, TX
- OSTI ID:
- 5446055
- Journal Information:
- Biochemistry; (United States), Journal Name: Biochemistry; (United States) Vol. 26:24; ISSN BICHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Organization of the human /alpha//sub 2/-plasmin inhibitor gene
Physical mapping of four serpin genes: [alpha][sub 1]-antitrypsin, [alpha][sub 1]-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome 14q32. 1
A cell-specific enhancer of the mouse. cap alpha. 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites
Journal Article
·
Thu Sep 01 00:00:00 EDT 1988
· Proc. Natl. Acad. Sci. USA; (United States)
·
OSTI ID:5822121
Physical mapping of four serpin genes: [alpha][sub 1]-antitrypsin, [alpha][sub 1]-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome 14q32. 1
Journal Article
·
Sun Jan 31 23:00:00 EST 1993
· American Journal of Human Genetics; (United States)
·
OSTI ID:6572702
A cell-specific enhancer of the mouse. cap alpha. 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites
Journal Article
·
Mon Feb 29 23:00:00 EST 1988
· Mol. Cell. Biol.; (United States)
·
OSTI ID:7070741
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE PHOSPHATASE
AMINO ACID SEQUENCE
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
CHYMOTRYPSIN
DAYS LIVING RADIOISOTOPES
DNA
DNA POLYMERASES
ENZYME INHIBITORS
ENZYMES
ESTERASES
EVEN-ODD NUCLEI
GENES
HYBRIDIZATION
HYDROLASES
ISOTOPES
LIGHT NUCLEI
MOLECULAR STRUCTURE
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
NUCLEOTIDYLTRANSFERASES
ODD-ODD NUCLEI
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PHOSPHATASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
RADIOISOTOPES
RECOMBINANT DNA
SERINE PROTEINASES
SULFUR 35
SULFUR ISOTOPES
TRANSFERASES
59 BASIC BIOLOGICAL SCIENCES
ALKALINE PHOSPHATASE
AMINO ACID SEQUENCE
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
CHYMOTRYPSIN
DAYS LIVING RADIOISOTOPES
DNA
DNA POLYMERASES
ENZYME INHIBITORS
ENZYMES
ESTERASES
EVEN-ODD NUCLEI
GENES
HYBRIDIZATION
HYDROLASES
ISOTOPES
LIGHT NUCLEI
MOLECULAR STRUCTURE
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
NUCLEOTIDYLTRANSFERASES
ODD-ODD NUCLEI
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PHOSPHATASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
RADIOISOTOPES
RECOMBINANT DNA
SERINE PROTEINASES
SULFUR 35
SULFUR ISOTOPES
TRANSFERASES