Radionuclide quantitation of right-to-left intracardiac shunts in children

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.64.3.572· OSTI ID:5442793

Peter, C A; Armstrong, B E; Jones, R H

A simple, noninvasive method for measurement of right-to-left intracardiac shunts would enhance the management of patients with congenital heart disease. This study describes application of data processing techniques used previously in dye-indicator curves to data recorded during the initial transit of radioactive bolus through the central circulation. Radionuclide angiocardiograms were performed in 20 children, mean age 30 months, immediately after cardiac catheterization for congenital heart disease. The radionuclide data recorded over the carotid artery were used to replace arterial sampling required for dye indicators, and forward triangles were fitted to calculate the right-to-left shunt in an approach similar to that of Wood for indicator-dilution curves. Ten of the children had right-to-left shunts by Fick and radionuclide measurement, and 10 of the children with septal defects had no right-to-left shunt by either technique. Both the radionuclide and Fick measurements correlated well (r . 0.95). Therefore, radionuclide angiocardiographic data may be used for accurate calculation of right-to-left shunts in small children, eliminating the need for arterial sampling.

• OSTI ID: 5442793
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 64:3; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CONGENITAL DISEASES
DATA PROCESSING
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
HEART
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
PROCESSING
RADIOCARDIOGRAPHY
RADIOLOGY
RADIOPHARMACEUTICALS
THERAPY