Would I-123 Di-iodotyrosine provide a harmless deiodination test

Journal Article · Thu Dec 01 04:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:5442437

Aurengo, A; Savoie, F; Leger, A F; Savoie, J C

Defective iodotyrosine deiodinase activity may benefit from a specific treatment, thus requiring an unequivocal diagnosis. In reported cases this diagnosis has been obtained from an in vivo deiodination test making use of di-iodotyrosine (DIT) labeled either with I-131 or I-125. Dosimetric calculation indicates that such tests may result in unacceptable irradiation of the thyroid of a child wrongly suspected of having defective iodotyrosine deiodinase activity; therefore other methods are needed. The use of I-123 DIT is shown to be feasible, but even a 1:30 reduction in the thyroid dose still remains too high. Suppression of thyroid I/sup -/ uptake by ClO/sub 4//sup -/, together with I-125 DIT, eliminates almost all thyroid irradiation and provides a sensitive, harmless, and rapid test.

• Research Organization: Hopital de la Pitie, Paris, France
• OSTI ID: 5442437
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
AGE GROUPS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHILDREN
CHLORINE COMPOUNDS
CONGENITAL DISEASES
DIAGNOSIS
DIIODOTYROSINE
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HALOGEN COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
METABOLIC DISEASES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PERCHLORATES
RADIATION DOSES
RADIOISOTOPES
THYROID
UPTAKE