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Laryngeal acinic cell carcinoma following thyroid irradiation

Journal Article · · Otolaryngol. Head Neck Surg.; (United States)
; ;
Only three examples of acinic cell carcinoma of the larynx or trachea are found in the recent literature. A case of acinic cell carcinoma of the subglottic larynx and trachea was diagnosed and treated at the University of Virginia Medical Center. To our knowledge this is the first such case with a prior history of radiation to the neck. The patient is a 56-year-old woman who was irradiated for hyperthyroidism 46 years ago. When seen she also had parathyroid hyperplasia and multiple thyroid adenomas, conditions that frequently follow irradiation of the thyroid in children. These findings in this case support the concept that radiation may be responsible for inducing this tumor, which otherwise rarely occurs in this location. The use of electron microscopy was extremely useful in the diagnosis of this tumor. She was treated with total laryngectomy and right neck dissection and is now free of disease one year after surgery.
OSTI ID:
5441606
Journal Information:
Otolaryngol. Head Neck Surg.; (United States), Journal Name: Otolaryngol. Head Neck Surg.; (United States) Vol. 89:3 Pt 1; ISSN OHNSD
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DELAYED RADIATION EFFECTS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYPERTHYROIDISM
LARYNX
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
THYROID
TRACHEA