Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype

Journal Article · Fri Jan 01 04:00:00 EST 1982 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.155.1.339· OSTI ID:5441240

Singer, A; Hathcock, K S; Hodes, R J

To examine the possibility that the thymus determines the I region-restricted self-recognition repertoire expressed by T helper (TH) cells, thymic chimeras were constructed by transplanting allogeneic neonatal thymic lobes into congenitally athymic nude mice. Spleen TH cells from the thymic chimeras were themselves of nude host origin but only cooperated with B+ accessory cells of the thymic haplotype for primary in vitro responses to sheep erythrocytes and trinitrophenyl conjugate of keyhole limpet hemocyanin. Thus, these experiments demonstrate that the self-recognition repertoire expressed by TH cells is determined by the H-2 phenotype of the intrathymic environment in which the TH cells had differentiated.

• Research Organization: Immunology Branch, National Cancer Institute, Bethesda, Maryland
• OSTI ID: 5441240
• Journal Information: J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 155:1; ISSN JEMEA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
IMMUNOLOGY
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
ORGANS
PHENOTYPE
PHYSIOLOGY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
THYMUS
TRANSPLANTS
VERTEBRATES