Long-chain F-18 fatty acids for the study of regional metabolism in heart and liver; odd-even effects of metabolism in mice
In view of the potential usefulness of fluorine-tagged fatty acids in the study of regional metabolism in the heart and liver, the time courses of uptake and release of 9,10-(/sup 18/F)fluorostearic acid, 2-(/sup 18/F)fluorostearic acid, 16-(/sup 18/F)fluorohexadecanoic acid, 17-(/sup 18/F)fluoroheptadecanoic acid have been investigated in several organs of NMRI mice. Whereas 2-(/sup 18/F)fluorostearic acid shows very little uptake in the heart muscle but an increasing accumulation in the liver, the fatty acids with the F-18 label in the middle or at the end of the carbon chain exhibit uptake and elimination behavior similar to that of the analogous C-11-labeled compounds. After rapid concentration in the heart within 1 min, clearance takes place with fast and slow components. 16-(/sup 18/F)fluorohexadecanoic acid and 17-(/sup 18/F)fluoroheptadecanoic acid have different half-times of elimination. These differences are also reflected by the fact that nearly all the activity present in the heart can be recovered as fluoride(F-18) in the case of 17-(/sup 18/F)fluoroheptadecanoic acid, whereas practically no fluoride was found among the metabolites of 16-(/sup 18/F)fluorohexadecanoic acid. Similar differences were observed for the F-18 activity in bone. The results can be interpreted in terms of the odd-even rule: ..beta.. oxidation of even-numbered fatty acids ends up with (/sup 18/F)fluoroacetic acid, whereas the odd-numbered fatty acids give rise to ..beta..-(/sup 18/F)fluoropropionic acid. Only in the latter case does dehalogenation take place leading to free fluoride, whereas fluoroacetic acid undergoes further reactions in the citric acid cycle.
- Research Organization:
- Kernforschungsanlage, Julich, Germany
- OSTI ID:
- 5437388
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:11; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CLEARANCE
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISTRIBUTION
EXPERIMENTAL DATA
FLUORINE 18
FLUORINE ISOTOPES
GLANDS
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LIVER
MAMMALS
METABOLISM
METABOLITES
MICE
MOLECULAR STRUCTURE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES