Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90057-4· OSTI ID:5436583

Micaily, B; Vonderheid, E C; Brady, L W; Andrews, C

Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. The authors conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.

• Research Organization: Hahnemann Univ., Philadelphia, PA
• OSTI ID: 5436583
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:6
• Country of Publication: United States
• Language: English

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